Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists.

Abstract:

:The synthesis and structure-activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists.

journal_name

Bioorg Med Chem Lett

authors

Lange JH,den Hartog AP,van der Neut MA,van Vliet BJ,Kruse CG

doi

10.1016/j.bmcl.2009.08.007

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

5675-8

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01140-8

journal_volume

19

pub_type

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