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2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation.

Abstract：

:To obtain modulators for reducing mitochondrial damage by the inhibition of Aβ oligomer formation, 2-phenylbenzofuran derivatives were designed and prepared. Their inhibitory activity against Aβ fibril formation was screened using ThT fluorescence assay, and the effect of derivatives on mitochondrial function was evaluated using JC-1 and MTT assay. 2-Phenylbenzofuran derivatives with dimethylamino group at p-position had an excellent inhibitory activity against Aβ fibril formation. Particularly, compound 19m alleviated mitochondrial damage remarkably and possessed protective effects against Aβ-induced cytotoxicity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee YS,Kim HY,Youn HM,Seo JH,Kim Y,Shin KJ

doi

10.1016/j.bmcl.2013.08.087

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

5882-6

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01036-6

journal_volume

23

pub_type

杂志文章

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