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Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors.

Abstract：

:A group of (Z)-1,2-diphenyl-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]but-1-enes were synthesized using methodologies that will allow incorporation of a [(124)I]iodine substituent at the para-position of either the C-1 phenyl ring or the C-2 phenyl ring, or a [(18)F]OCH(2)CH(2)F substituent at the para-position of the C-2 phenyl ring. These [(124)I] and [(18)F] radiotracers are designed as potential radiopharmaceuticals to image estrogen positive breast tumors using positron emission tomography (PET).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Abdellatif KR,Velázquez CA,Huang Z,Chowdhury MA,Knaus EE

doi

10.1016/j.bmcl.2010.12.091

subject

Has Abstract

pub_date

2011-02-15 00:00:00

pages

1195-8

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01855-X

journal_volume

21

pub_type

杂志文章

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