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Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.

Abstract：

:4'-Modified noraristeromycin (NAM) analogs, 4'-sulfo-, 4'-sulfamoy, 4'-azido and 4'-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl-L-homocysteine hydrolase were investigated.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ando T,Kojima K,Chahota P,Kozaki A,Milind ND,Kitade Y

doi

10.1016/j.bmcl.2008.03.029

subject

Has Abstract

pub_date

2008-04-15 00:00:00

pages

2615-8

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00302-8

journal_volume

18

pub_type

杂志文章

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