The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds.

Abstract:

:We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.

journal_name

Bioorg Med Chem Lett

authors

Fernández D,Wenck MA,Craig SP 3rd,Delfino JM

doi

10.1016/j.bmcl.2004.06.042

subject

Has Abstract

pub_date

2004-09-06 00:00:00

pages

4501-4

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960894X04007978

journal_volume

14

pub_type

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