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Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B.

Abstract：

:Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Laurin P,Ferroud D,Schio L,Klich M,Dupuis-Hamelin C,Mauvais P,Lassaigne P,Bonnefoy A,Musicki B

doi

10.1016/s0960-894x(99)00492-8

subject

Has Abstract

pub_date

1999-10-04 00:00:00

pages

2875-80

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X99004928

journal_volume

9

pub_type

杂志文章

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