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Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.

Abstract：

:The synthesis and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated, and some of these derivatives showed better in vitro antibacterial activity than existing drugs, including penicillin, ciprofloxacin, vancomycin, and linezolid.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shi W,Duan Y,Qian Y,Li M,Yang L,Hu W

doi

10.1016/j.bmcl.2010.04.123

subject

Has Abstract

pub_date

2010-06-15 00:00:00

pages

3592-5

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00601-3

journal_volume

20

pub_type

杂志文章

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