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Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.

Abstract：

:In order to establish structural elements responsible for inhibition of trypanothione reductase (TR) from Trypanosoma cruzi by 2-aminodiphenylsulfides, a series of dissymmetrical derivatives, corresponding to the replacement of one aromatic moiety by different amines, was synthesized. TR inhibition studies revealed the importance of the aromatic rings and of the amino groups in the side chains for potent inhibition. Quinonic moities were also introduced with the aim of acting as TR redox-cycling substrates.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Girault S,Davioud-Charvet E,Salmon L,Berecibar A,Debreu MA,Sergheraert C

doi

10.1016/s0960-894x(98)00180-2

subject

Has Abstract

pub_date

1998-05-19 00:00:00

pages

1175-80

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X98001802

journal_volume

8

pub_type

杂志文章

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