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Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands.

Abstract：

:A novel series of imidazo[1,5-a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hartz RA,Gilligan PJ,Nanda KK,Tebben AJ,Fitzgerald LW,Miller K

doi

10.1016/s0960-894x(01)00741-7

subject

Has Abstract

pub_date

2002-02-11 00:00:00

pages

291-4

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960894X01007417

journal_volume

12

pub_type

杂志文章

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