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Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors.

Abstract：

:Modification of the major insecticide fipronil (1) by replacing three pyrazole substituents (hydrogen for both cyano and amino and trifluoromethyldiazirinyl for trifluoromethylsulfinyl) gives a candidate photoaffinity probe (3) of high potency (IC(50) 2-28 nM) in blocking the chloride channel of Drosophila and human beta 3 GABA receptors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sirisoma NS,Ratra GS,Tomizawa M,Casida JE

doi

10.1016/s0960-894x(01)00604-7

subject

Has Abstract

pub_date

2001-11-19 00:00:00

pages

2979-81

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960894X01006047

journal_volume

11

pub_type

杂志文章

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