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Identification of arylsulfonamides as ExoU inhibitors.

Abstract：

:ExoU is a potent virulence factor of Pseudomonas aeruginosa and is considered a potential therapeutic target. In order to discover novel ExoU inhibitors, we screened an in-house chemical library utilizing a yeast-based screening system. Some sulfonamides displayed significant activity without nonspecific cytotoxicity. We describe a series of sulfonamides as novel ExoU inhibitors, along with a brief structure-activity relationship.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kim D,Baek J,Song J,Byeon H,Min H,Min KH

doi

10.1016/j.bmcl.2014.06.064

subject

Has Abstract

pub_date

2014-08-15 00:00:00

pages

3823-5

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00692-1

journal_volume

24

pub_type

杂志文章

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