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Sordarin oxazepine derivatives as potent antifungal agents.

Abstract：

:The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Serrano-Wu MH,St Laurent DR,Chen Y,Huang S,Lam KR,Matson JA,Mazzucco CE,Stickle TM,Tully TP,Wong HS,Vyas DM,Balasubramanian BN

doi

10.1016/s0960-894x(02)00529-2

subject

Has Abstract

pub_date

2002-10-07 00:00:00

pages

2757-60

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X02005292

journal_volume

12

pub_type

杂志文章

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