Abstract:
:Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioavailability and PK/PD profile in ZF-rat.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Nishio Y,Kimura H,Tosaki S,Sugaru E,Sakai M,Horiguchi M,Masui Y,Ono M,Nakagawa T,Nakahira Hdoi
10.1016/j.bmcl.2010.10.101subject
Has Abstractpub_date
2010-12-15 00:00:00pages
7246-9issue
24eissn
0960-894Xissn
1464-3405pii
S0960-894X(10)01562-3journal_volume
20pub_type
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