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Structure-activity relationships studies of the anti-angiogenic activities of linomide.

Abstract：

:The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shi J,Xiao Z,Ihnat MA,Kamat C,Pandit B,Hu Z,Li PK

doi

10.1016/s0960-894x(03)00047-7

subject

Has Abstract

pub_date

2003-03-24 00:00:00

pages

1187-9

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X03000477

journal_volume

13

pub_type

杂志文章

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