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Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp.

Abstract：

:A new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system, named penicinoline (1) was isolated from a mangrove endophytic fungus. The structure of 1 was elucidated by spectroscopic methods and comparison with its derivative, penicinotam (1a), an unexpected lactam that was obtained from 1 by intramolecular dehydration. The structure of 1a was unambiguously confirmed by single-crystal X-ray analysis. Penicinoline (1) showed potent in vitro cytotoxicity toward 95-D and HepG2 cell lines with IC(50) values of 0.57 and 6.5 microg/mL, respectively.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shao CL,Wang CY,Gu YC,Wei MY,Pan JH,Deng DS,She ZG,Lin YC

doi

10.1016/j.bmcl.2010.04.043

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

3284-6

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00513-5

journal_volume

20

pub_type

杂志文章

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