Abstract:
:10, 15, 20-Triphenyl-5-(4-hydroxy-3-(trimethylammonium)methyl)phenylporphyrin 4 and its zinc complex 5 have been synthesized and antibacterial activities have been studied for 4 and its derivative. Compound 4 showed stronger inhibition than that of 10, 15, 20-triphenyl-5-(4-hydroxy-3-(dimethylamine)methyl)phenylporphyrin (2) and 10, 15, 20-triphenyl-5-(4-methoxy-3-(trimethylammonium)methyl)phenylporphyrin (6). It is possible that antibacterial activity of compound 4 involved in photoinducing both o-quinone methide intermediate and singlet oxygen formation.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Zhang J,Wu X,Cao X,Yang F,Wang J,Zhou X,Zhang XLdoi
10.1016/s0960-894x(03)00053-2subject
Has Abstractpub_date
2003-03-24 00:00:00pages
1097-100issue
6eissn
0960-894Xissn
1464-3405pii
S0960894X03000532journal_volume
13pub_type
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