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Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A.

Abstract：

:A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee HY,Jung Y,Kim W,Kim JH,Suh MS,Shin SK,Yoon HJ

doi

10.1016/j.bmcl.2008.07.006

subject

Has Abstract

pub_date

2008-08-15 00:00:00

pages

4670-4

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00773-7

journal_volume

18

pub_type

杂志文章

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