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Triple recognition of B-DNA.

Abstract：

:A novel conjugate of Hoechst 33258, pyrene and neomycin was synthesized and examined for its binding and stabilization of A-T rich DNA duplexes using spectroscopic and viscometric techniques. The conjugate, containing three well known ligands that bind nucleic acids albeit in different binding modes, was found to significantly stabilize DNA over parent conjugates containing only one or both of the other recognition elements. The study represents the first example of DNA molecular recognition capable of minor/major groove recognition in conjunction with intercalation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Willis B,Arya DP

doi

10.1016/j.bmcl.2009.07.079

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

4974-9

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01030-0

journal_volume

19

pub_type

杂志文章

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