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Interaction between morphine and lysine.

Abstract：

:The study by the molecular orbital theory displayed that morphine and lysine make two types of the interactions between them: type (A) by three hydrogen bondings and type (B) by one hydrogen bonding accompanied with a proton transfer. The stabilization energies were 45.3 and 34.9 kcal/mol for type (A) and type (B), respectively. The characters of these interactions are striking compared to the interactions of morphine with the other amino acids, suggesting that lysine is the binding point of morphine in the mu-opioid receptor.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nakai S,Yoneda F

doi

10.1016/s0960-894x(01)00228-1

subject

Has Abstract

pub_date

2001-06-04 00:00:00

pages

1383-7

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(01)00228-1

journal_volume

11

pub_type

杂志文章

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