Abstract:
:The efficient synthesis of an enzyme cleavable biotinylated diazirinyl photoaffinity ligand is described to allow the effective manipulation of the photolabeled biocomponents. The compound contains a glutamic acid gamma-methyl ester, which is a precursor of the substrate for V8 protease, between the diazirinyl photophor and biotin moiety. After alkaline hydrolysis of the ester, the compound can be proteolyzed at the Glu moiety by V8 protease. The photophore was introduced to L-Phe p-nitroanilide and the ligand was applied to photolabel of chymotrypsin to manipulate the application of the concept.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Hashimoto M,Okamoto S,Nabeta K,Hatanaka Ydoi
10.1016/j.bmcl.2004.03.011subject
Has Abstractpub_date
2004-05-17 00:00:00pages
2447-50issue
10eissn
0960-894Xissn
1464-3405pii
S0960894X04003439journal_volume
14pub_type
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