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Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

Abstract：

:A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Calderwood DJ,Johnston DN,Munschauer R,Rafferty P

doi

10.1016/s0960-894x(02)00195-6

subject

Has Abstract

pub_date

2002-06-17 00:00:00

pages

1683-6

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960894X02001956

journal_volume

12

pub_type

杂志文章

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