Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

Abstract:

:A series of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed excellent selectivity at hNET that appeared superior to those of reboxetine and atomoxetine (4 and 5).

journal_name

Bioorg Med Chem Lett

authors

Zhang P,Terefenko EA,McComas CC,Mahaney PE,Vu A,Trybulski E,Koury E,Johnston G,Bray J,Deecher D

doi

10.1016/j.bmcl.2008.10.026

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

6067-70

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01219-5

journal_volume

18

pub_type

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