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Total synthesis of mololipids: a new series of anti-HIV Moloka'iamine derivatives.

Abstract：

:A new family of bioactive bromotyrosine derivatives, termed mololipids, was recently isolated from a Hawaiian sponge, but could not be resolved into individual components by chromatography. To complete their structural characterization and better understand structure-activity relationships, the first pure samples of dimyristoyl, distearoyl, dioleoyl, and stearoyl/oleoyl mololipids have now been prepared by total synthesis, and their anti-HIV activity investigated.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Schoenfeld RC,Lumb JP,Fantini J,Ganem B

doi

10.1016/s0960-894x(00)00543-6

subject

Has Abstract

pub_date

2000-12-04 00:00:00

pages

2679-81

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00543-6

journal_volume

10

pub_type

杂志文章

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