Abstract:
:Two series of 5-phenyl furocoumarin derivatives were designed and prepared based on our previous research. All new compounds were characterized by (1)H NMR, (13)C NMR and mass spectra. Furthermore, they were screened for their vasodilatory activity on the mesenteric artery of Sprague-Dawley rats, and they all presented with moderate vasodilatory activity. Fluorescent properties of the target compounds were tested in methanol. The fluorescence variation of 4a was investigated in different solvents, various pH and the migration time was determined. All results indicated that this type of fluorescent compound can be used as vasodilatory agents and probes simultaneously after further structural modifications.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Wang C,Wang T,Huang L,Lu W,Zhang J,He Hdoi
10.1016/j.bmcl.2015.11.056subject
Has Abstractpub_date
2016-01-15 00:00:00pages
640-644issue
2eissn
0960-894Xissn
1464-3405pii
S0960-894X(15)30264-Xjournal_volume
26pub_type
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