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Development of an affinity-driven cross-linker: isolation of a vitamin D receptor associated factor.

Abstract：

:A vitamin D analogue containing an affinity and a photoaffinity probe (affinity-driven cross-linker, Double Label) was synthesized. An unknown factor, associated with vitamin D receptor (VDR), was isolated from rat liver nuclear extract using a GST-VDR-ligand-binding domain fusion protein (GST-VDR-LBD), affinity labeled with Double Label, and protein-protein cross-linking by photolysis.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Swamy N,Addo JK,Ray R

doi

10.1016/s0960-894x(00)00009-3

subject

Has Abstract

pub_date

2000-02-21 00:00:00

pages

361-4

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00009-3

journal_volume

10

pub_type

杂志文章

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