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Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects.

Abstract：

:A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ju C,Song S,Hwang S,Kim C,Kim M,Gu J,Oh YK,Lee K,Kwon J,Lee K,Kim WK,Choi Y

doi

10.1016/j.bmcl.2013.07.038

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

5421-5

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00883-4

journal_volume

23

pub_type

杂志文章

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