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An efficient and versatile approach for the construction of oligonucleotide microarrays.

Abstract：

:A new immobilization chemistry for covalent attachment of phosphorylated oligonucleotides on epoxy-activated glass surface via opening of oxirane ring is described. The proposed strategy results in excellent immobilization efficiency, spot homogeneity, and morphology. The constructed microarray was successfully demonstrated for discrimination of nucleotide mismatches.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Mahajan S,Kumar P,Gupta KC

doi

10.1016/j.bmcl.2006.08.014

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

5654-8

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00905-X

journal_volume

16

pub_type

杂志文章

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