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Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts.

Abstract：

:The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4-20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Naidu BN,Sorenson ME,Bronson JJ,Pucci MJ,Clark JM,Ueda Y

doi

10.1016/j.bmcl.2005.02.046

subject

Has Abstract

pub_date

2005-04-15 00:00:00

pages

2069-72

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00220-9

journal_volume

15

pub_type

杂志文章

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