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Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.

Abstract：

:A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sheng R,Lin X,Li J,Jiang Y,Shang Z,Hu Y

doi

10.1016/j.bmcl.2005.05.132

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

3834-7

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00745-6

journal_volume

15

pub_type

杂志文章

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