Abstract:
:A series of (S)-N-(1,4-naphthoquinon-2-yl)-alpha-amino acid methyl esters 3-9, 2-N,N-dialkylamino-1,4-naphthoquinones 10-11 and 2-hydroxy-3-(2'-mercaptoimidazolyl)-1,4-naphthoquinones and their cyclic analogs 12-15 were synthesized and evaluated for antifungal and antibacterial activities. The structure-activity relationships of these compounds were studied and the results show that the compounds 9b and 13c exhibited in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, and Sporothrix schenckii, whereas compound 6a showed in vitro antibacterial activity against Streptococcus faecalis, K. pneumoniae, Escherichia coli, and Staphylococcus aureus.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Tandon VK,Yadav DB,Singh RV,Chaturvedi AK,Shukla PKdoi
10.1016/j.bmcl.2005.08.032subject
Has Abstractpub_date
2005-12-01 00:00:00pages
5324-8issue
23eissn
0960-894Xissn
1464-3405pii
S0960-894X(05)01027-9journal_volume
15pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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