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Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.

Abstract：

:The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Leonik FM,Papke RL,Horenstein NA

doi

10.1016/j.bmcl.2007.01.003

subject

Has Abstract

pub_date

2007-03-15 00:00:00

pages

1520-2

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00034-0

journal_volume

17

pub_type

杂志文章

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