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Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.

Abstract：

:Retinoid X Receptor (RXR) specific ligands are currently being investigated for the treatment of metabolic diseases such as type II diabetes. We report the synthesis of conformationally locked retinoids, which are potent RXR selective ligands, and the attempted synthesis of 9-cyclopropyl locked analogs of RA and 9-cis RA.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Vuligonda V,Garst ME,Chandraratna RA

doi

10.1016/s0960-894x(99)00048-7

subject

Has Abstract

pub_date

1999-02-22 00:00:00

pages

589-94

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960894X99000487

journal_volume

9

pub_type

杂志文章

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