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Synthesis of lipopolyhydroxylalkyleneamines for gene delivery.

Abstract：

:Various bis(2-hydroxy-3-chloropropyl)alkylamines were synthesized by coupling primary amine with epichlorohydrin and utilized as a monomer to react with ethylenediamine (EDA), N,N'-dimethylethylenediamine (DMEDA), or tetramethylethylenediamine (TMEDA) to generate a series of lipopolyhydroxylalkyleneamines. The number- and weight-average molecular weight (Mn and Mw) and polydispersity index (Mw/Mn) of the lipopolyhydroxylalkyleneamines were dependent on reactant solvent and reaction temperature. The compounds with EDA as backbone have better transfection activity and lower toxicity than those with DMEDA and TMEDA as backbone.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Li Q,Zhang G,Marhefka J,Kameneva MV,Liu D

doi

10.1016/j.bmcl.2006.01.120

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

2428-32

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00165-X

journal_volume

16

pub_type

杂志文章

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