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Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.

Abstract：

:This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee JY,Park SJ,Park SJ,Lee MJ,Rhim H,Seo SH,Kim KS

doi

10.1016/j.bmcl.2006.07.046

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

5014-7

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00820-1

journal_volume

16

pub_type

杂志文章

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