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Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues.

Abstract：

:The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wang Y,Zhang F,Zhang Y,Liu JO,Ma D

doi

10.1016/j.bmcl.2008.06.066

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

4385-7

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00715-4

journal_volume

18

pub_type

杂志文章

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