Abstract:
:We report, for the first time, that certain N-acetylthiourea derivatives serve as highly potent and isozyme selective activators for the recombinant form of human histone deacetylase-8 in the assay system containing Fluor-de-Lys as a fluorescent substrate. The experimental data reveals that such activating feature is manifested via decrease in the K(m) value of the enzyme's substrate and increase in the catalytic turnover rate of the enzyme.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Singh RK,Mandal T,Balsubramanian N,Viaene T,Leedahl T,Sule N,Cook G,Srivastava DKdoi
10.1016/j.bmcl.2011.07.080subject
Has Abstractpub_date
2011-10-01 00:00:00pages
5920-3issue
19eissn
0960-894Xissn
1464-3405pii
S0960-894X(11)01026-2journal_volume
21pub_type
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