Abstract:
:Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3'- and 4'-demethylnobiletin) and di-demethylation (3',4'-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Li S,Sang S,Pan MH,Lai CS,Lo CY,Yang CS,Ho CTdoi
10.1016/j.bmcl.2007.06.096subject
Has Abstractpub_date
2007-09-15 00:00:00pages
5177-81issue
18eissn
0960-894Xissn
1464-3405pii
S0960-894X(07)00793-7journal_volume
17pub_type
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