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Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.

Abstract：

:Novel derivatives of the D-glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol bearing lipophilic aliphatic or aromatic amides attached to C-1 have been found to inhibit beta-glucosidase from Agrobacterium sp. in the nanomolar range. One of them, a coumarin derivative, ranks amongst the most active compounds in the class of reversible glycosidase inhibitors of the iminoalditol type.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wrodnigg TM,Withers SG,Stütz AE

doi

10.1016/s0960-894x(01)00126-3

subject

Has Abstract

pub_date

2001-04-23 00:00:00

pages

1063-4

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(01)00126-3

journal_volume

11

pub_type

杂志文章

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