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Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.

Abstract：

:Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Finn J,Mattia K,Morytko M,Ram S,Yang Y,Wu X,Mak E,Gallant P,Keith D

doi

10.1016/s0960-894x(03)00298-1

subject

Has Abstract

pub_date

2003-07-07 00:00:00

pages

2231-4

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X03002981

journal_volume

13

pub_type

杂志文章

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