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Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.

Abstract：

:Selective σ2 ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the σ2-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (DAT), yielding a highly selective DAT ligand.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Motel WC,Healy JR,Viard E,Pouw B,Martin K,Matsumoto RR,Coop A

doi

10.1016/j.bmcl.2013.09.038

subject

Has Abstract

pub_date

2013-12-15 00:00:00

pages

6920-6922

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01112-8

journal_volume

23

pub_type

杂志文章

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