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Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.

Abstract：

:A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against alpha(2)delta and was profiled in in vivo models of pain and anxiety.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Blakemore DC,Bryans JS,Carnell P,Field MJ,Kinsella N,Kinsora JK,Meltzer LT,Osborne SA,Thompson LR,Williams SC

doi

10.1016/j.bmcl.2009.10.121

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

248-51

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01542-X

journal_volume

20

pub_type

杂志文章

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