Abstract:
:Backbone-modified DNA analogs were synthesized in good yields by the boranophosphotriester method on a solid support. The oligodeoxyribonucleoside boranophosphates, protected with 2-(azidomethyl)benzoyl groups for nucleobases, were converted into DNA and its backbone-modified analogs via the corresponding H-phosphonate intermediates. A new protecting group for the O6 position of 2'-deoxyguanosine, 4-azidobenzyl (ABn) group, was also developed. The ABn group can be quickly removed by treatment with MePPh2 and H2O in the presence of 2-mercaptoethanol.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Kawanaka T,Shimizu M,Shintani N,Wada Tdoi
10.1016/j.bmcl.2008.05.053subject
Has Abstractpub_date
2008-07-01 00:00:00pages
3783-6issue
13eissn
0960-894Xissn
1464-3405pii
S0960-894X(08)00534-9journal_volume
18pub_type
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