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Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.

Abstract：

:A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Obi K,Uda J,Iwase K,Sugimoto O,Ebisu H,Matsuda A

doi

10.1016/s0960-894x(00)00256-0

subject

Has Abstract

pub_date

2000-07-03 00:00:00

pages

1451-4

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X00002560

journal_volume

10

pub_type

杂志文章

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