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Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.

Abstract：

:A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD(+)-dependent DNA ligase that possess potency against Gram-positive bacteria.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wang T,Duncan L,Gu W,O'Dowd H,Wei Y,Perola E,Parsons J,Gross CH,Moody CS,Arends SJ,Charifson PS

doi

10.1016/j.bmcl.2012.04.038

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

3699-703

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00477-5

journal_volume

22

pub_type

杂志文章

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