Abstract:
:A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Smith AB 3rd,Sasho S,Barwis BA,Sprengeler P,Barbosa J,Hirschmann R,Cooperman BSdoi
10.1016/s0960-894x(98)00575-7subject
Has Abstractpub_date
1998-11-17 00:00:00pages
3133-6issue
22eissn
0960-894Xissn
1464-3405pii
S0960894X98005757journal_volume
8pub_type
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