Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla.

Abstract:

:Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively.

journal_name

Bioorg Med Chem Lett

authors

Lee JS,Yang MY,Yeo H,Kim J,Lee HS,Ahn JS

doi

10.1016/s0960-894x(99)00211-5

subject

Has Abstract

pub_date

1999-05-17 00:00:00

pages

1429-32

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X99002115

journal_volume

9

pub_type

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