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Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II.

Abstract：

:A series of methoxycarbonyl group modified nidulalin A analogs were synthesized to improve stability against esterases. The amide derivatives showed cytotoxic activity along with inhibitory activity against DNA topoisomerase II. Among the analogs, amide 9a exhibited antitumor activity in Colon 26 murine tumor model.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sato S,Suga Y,Yoshimura T,Nakagawa R,Tsuji T,Umemura K,Andoh T

doi

10.1016/s0960-894x(99)00440-0

subject

Has Abstract

pub_date

1999-09-20 00:00:00

pages

2653-6

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960894X99004400

journal_volume

9

pub_type

杂志文章

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