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A facile synthesis, antibacterial activity of pulvinone and its derivatives.

Abstract：

:Pulvinone and several 3-fluoro-4-morpholino substituted pulvinone derivatives were synthesized in five steps from a common precursor, phenyl acetic acid. Most of synthetic morpholine substituted pulvinones showed inhibitory activity against Esherichia coli. For the first time, the inhibition of pulvinone and its derivatives against Gram-negative bacteria was reported.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Xu HW,Xu C,Fan ZQ,Zhao LJ,Liu HM

doi

10.1016/j.bmcl.2012.11.090

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

737-9

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)01542-9

journal_volume

23

pub_type

杂志文章

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