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A selective phosphine-based fluorescent probe for nitroxyl in living cells.

Abstract：

:A novel fluorescein-based fluorescent probe for nitroxyl (HNO) based on the reductive Staudinger ligation of HNO with an aromatic phosphine was prepared. This probe reacts with HNO derived from Angeli's salt and 4-bromo Piloty's acid under physiological conditions without interference by other biological redox species. Confocal microscopy demonstrates this probe detects HNO by fluorescence in HeLa cells and mass spectrometric analysis of cell lysates confirms this probe detects HNO following the proposed mechanism.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Miao Z,Reisz JA,Mitroka SM,Pan J,Xian M,King SB

doi

10.1016/j.bmcl.2014.11.041

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

16-9

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)01225-6

journal_volume

25

pub_type

杂志文章

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