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Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole.

Abstract：

:Synthesis of novel 1,2,3-triazole-linked beta-lactam-bile acid conjugates 17-24 using 1,3-dipolar cycloaddition reaction of azido beta-lactam and terminal alkyne of bile acids in the presence of Cu(I) catalyst (click chemistry) have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and moderate antibacterial activity against all the tested strains.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Vatmurge NS,Hazra BG,Pore VS,Shirazi F,Chavan PS,Deshpande MV

doi

10.1016/j.bmcl.2008.01.102

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

2043-7

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00130-3

journal_volume

18

pub_type

杂志文章

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